Leonardo has made three changes to the side that beat Fiorentina in Serie A at the weekend with Lucio and Yuto Nagatomo part of a defensive reshuffle
Marco Materazzi and Andrea Ranocchia make way with Cristian Chivu dropping into the centre of defence alongside the experienced Lucio. Japanese international Nagatomo will start the game at left-back for Leonardo's men.
The only other change for Inter is the introduction of MacDonald Mariga who will line-up in midfield in place of Philippe Coutinho with Houssine Kharja playing in a more advanced role behind the strikers.
Roma make several changes to the side who drew 0-0 with AC Milan at the weekend with Marco Borriello, Jeremy Menez, Simone Perrotta and Daniele De Rossi coming into the starting XI.
Inter hold a 1-0 lead from the first leg where Dejan Stankovic scored the only goal of the game at the Olimpico.
Inter (4-3-1-2): Julio Cesar; Maicon, Lucio, Chivu, Nagatomo; Mariga, Cambiasso, Zanetti; Kharja; Eto'o, Pazzini.
Subs: Castellazzi, Thiago Motta, Obi, Milito, Materazzi, Pandev, Coutinho.
Roma (4-2-3-1): Doni; Cassetti, Burdisso, Juan, Riise; Pizarro, De Rossi; Perrotta, Simplicio Menez; Borriello.
Subs: Lobont, Castellini, Vucinic, Lloria, Greco, Caprari, Rosi.