Inter will be without Esteban Cambiasso for Sunday's trip to Sampdoria after it was confirmed a thigh strain suffered against Bayern Munich will keep him out of action.
The club said Cambiasso suffered a "strain to his adductor muscle" via a statement on their official website following tests on Friday.
But his timescale of recovery is yet to be established.
Leonardo has a number of issues to deal with as injuries and suspensions will see a weak Inter squad travel to Genoa.
Thiago Motta is in doubt, while Andrea Ranocchia and Ivan Cordoba are unlikely to make the cut for defence. Ranocchia suffered a knee ligament strain after clashing with Cristian Chivu against Bayern, while Cordoba has an ankle problem.
Walter Samuel is still out for the long term, while Maicon is suspended for Sunday's 20:45 CET kick-off.