The stadium will be packed for the Serie A showdown...
Although there are still 48 hours to go until the crunch clash, all tickets have been sold and close to 70,000 spectators are expected to be present at the Stadio Olimpico.
It is a crucial contest for both sides as they are looking to keep their title hopes alive by staying within touching distance of Inter. Roma are currently seven points behind the Nerazzurri, while the Rossoneri are four points back of the league-leaders.
During the first-half of Serie A, this match ended 2-1 in favour of Milan with Alexandre Pato scoring the winner. However, the young Brazilian will miss the match due to injury. Another superstar who will be missing is Roma captain Francesco Totti, but Luca Toni is expected to return after a five-week injury lay-off.
La Gazzetta dello Sport reveals the probable line-ups:
ROMA (4-2-3-1): Julio Sergio; Motta, Mexes, Juan, Riise; Brighi, De Rossi; Taddei, Perrotta, Vucinic; Toni.
MILAN (4-3-3): Abbiati; Bonera, Nesta, Thiago Silva, Jankulovski; Flamini, Pirlo, Ambrosini; Mancini, Borriello, Ronaldinho.