A Javier Hernandez brace saw Manchester United swot aside Wigan Athletic and claim a four-point lead over Arsenal at the top of the Premier League table.
The Mexican was at his ruthless best as his strikes put United in control. Rooney then found the net for just the seventh time this season in all competitions before substitute Fabio put the icing on the cake.
For the hosts, manager Roberto Martinez made nine changes to the side that lost 1-0 in the F.A. Cup to Bolton Wanderers last week. In a repeat of the team that drew 1-1 at Liverpool, Gary Caldwell and Mohamed Diame were the only survivors from the previous match as star men such as Charles N'Zogbia and Hugo Rodallega were restored to the starting line-up.
United boss Sir Alex Ferguson made two changes to the side that drew 0-0 at Marseille in the Champions League on Wednesday. Javier Hernandez was selected in place of leading scorer Dimitar Berbatov, while Paul Scholes was tasked with pulling the strings in midfield in place of Darron Gibson.
Wigan - chasing a first point against United in 11 meetings - started the brighter. In the sixth minute, Diame picked up on a loose pass from Scholes in the middle of the pitch and stretched his long legs and played in Rodallega.
With Nemanja Vidic on the cover, the Colombian's inviting low centre was stabbed away for a corner by John O'Shea with Victor Moses positioned dangerously.
Serious questions were asked of referee Mark Clattenburg a minute later as Wayne Rooney appeared to elbow James McCarthy. With the DW Stadium crowd baying for blood, the official chose instead to just blow for a free-kick rather than delve into his pocket for a card.
The reprieve seemed to temporarily lift United and a ball over the top from Rooney was scrambled into Darren Fletcher's path in the penalty area. The Scot's cross was then inches away from finding Hernandez.
United's grip was suddenly threatened in the 12th minute when Scholes - who temporarily found himself the right-back berth - uncharacteristically rushed a clearance which cannoned off Moses' back. Clean through on goal, the ex-Crystal Palace youngster was foiled by the giant frame of Edwin van der Sar.
The game swinged from end to end and Hernandez found himself one-on-one against Maynor Figueroa, but the Honduras international stood his ground and expertly tackled the Mexican.
Hernandez wasn't to be kept out for long and he opened the scoring in the 17th minute. Rooney - whose every touch was booed - played in Nani on the left flank and the Portuguese's low cross was flicked in expertly by the Mexican for his 12th goal of his promising debut campaign.
Wigan were unlucky to fall behind after they had set the pace for much of the opening period. Immediately from the kick-off, a goal mouth scramble saw the ball fall to McCarthy in space just five yards from goal but van der Sar again smothered the threat.
An equaliser seemed more likely than a second goal for United up until the 25 minute mark, but then the 'Ginger Maestro' Scholes was allowed to get his foot on the ball.
An excellent team move three minutes later - orchestrated by the veteran playmaker - saw swift footwork from Fletcher and Rooney lead to Nani collecting the ball on the charge. The winger unleashed a fearsome drive that beat goalkeeper Ali Al Habsi but smashed back off his near post to keep Wigan in the contest.
The Wigan crowd again took issue with Clattenburg's refeering in the 35th minute when Scholes committed a trademark late sweep through McCarthy's legs. Despite the nature of the foul, the official again refused to show a card.
United continued to stay in control of proceedings for the rest of the half as Ferguson - and on pitch general Scholes - dictated play.
United started much the brighter in the second period but it was Wigan who first threatened through left-back Figueroa. The Honduran requires no invite to strike from distance and a trademark thunderbolt was palmed away to safety by van der Sar in the 47th minute.
This was to be a highlight for the host's in the opening minutes of the restart as their opponents grabbed a firm grip of the game. In the 52nd minute, Nani twisted inside his marker and his shot from 10 yards on the angle was almost deflected past Al Habsi by Caldwell.
United had now picked up the pace and Wigan were just about holding on. In the 54th minute, goalscorer Hernandez almost set up Nani with a cross before the Mexican struck the side-netting in the aftermath.
A rare attack from Wigan followed as the ball was cleared forward. Vidic was out-manouvered by Rodallega as he attempted to clear, but Moses could only fire a conversion effort worthy of Rugby League side Wigan Warriors over van der Sar's crossbar.
Wigan looked ripe for the kill by the league leaders and Nani and Fletcher almost sealed the win in the 59th minute. First, Nani cut inside to hit a weak shot that was spilled by Al Habsi, but he redeemed himself immediately by being quick on his feet to keep out the Scot after he was played in by Rooney five yards from goal.
The host's were unlucky to find United in aggressive mode after a camopaign pockmarked by poor away form. Ferguson was desperate for his players to claim all three points and in the 72nd minute Rooney twice went close to doubling the lead.
First, his header from a Nani cross was cleared en-route to Al Habsi's goal by Caldwell. In the ensuing play, he then harmlessly nodded the ball into the Bolton loanee's hands from an O'Shea centre.
While it proved to be another frustrating afternoon in front of goal for Rooney, he played a key role in Hernandez securing his brace in the 74th minute. A long clearance from van der Sar was brought under control by the number 10, who then proceded to play the Mexican clear through on goal with an incisive one-two.
Hernandez, with confidence souring through his system, then slotted past the Oman international.
Not satisfied with the lead, United continued to find holes in the Latics' pourous defence. Rooney had played second fiddle to Hernandez, but the Mexican's substitute Berbatov set him up with a chance in the 84th minute that he couldn't miss.
The Bulgarian was played in by a cutting long ball from fellow replacement Gibson and unselfishly laid the ball to Rooney to place into an open net.
A four-point lead over Arsenal at the top of the standings was now guaranteed and Fabio mirrored this with the scoreline. A deep cross from Fletcher was too hot for Rooney to handle but the Brazilian substitute picked up the ball unmarked on the back stick with his first touch of the match to make it 4-0.
Wigan had proved easy pickings for United. Ferguson will hope his side can ride this wave past Chelsea and Liverpool in the coming week to put one hand on the trophy.