Jurgen Klinsmann's side struck twice late on in Kansas City against the Caribbean nation to ensure North American dominance
Jurgen Klinsmann's men were made to work hard for victory, but two goals in the final 15 minutes from Graham Zusi and Jozy Altidore allowed them to secure all three points.
The result of Friday's World Cup qualifier was basically irrelevant as the USA had already qualified for next year's tournament in Brazil, while Jamaica had no chance of qualifying.
And the game seemed to reflect that for the opening 70 minutes with a lack of urgency meaning there were only four shots that tested either goalkeeper in that time.
With World Cup qualification already secure, the USA's head coach Jürgen Klinsmann took the opportunity to give a starting debut to Icelandic-born striker Aron Johannson.
But it was not until Johannson was substituted that the hosts finally hit the back of the net with Zusi finishing off a nice cutback by Alejandro Bedoya in the 77th minute.
The Americans then opened up Jamaica's defence in the 81st minute with Edgar Castillo getting free on the left-hand side to set up Altidore for a simple tap in from close range.
The victory continued the USA's incredible run of form that stretches back to June, while Jamaica suffered their fifth defeat in seven World Cup qualifiers.
Klinsmann's team moved to 19 points at the top of Concacaf's standings, four points clear of second-placed Costa Rica, while Jamaica (four points) remain bottom of the six-team group.