The Chilean's title contenders have won their last seven Premier League games in a row but Spurs have gained three points in all but one of their league matches under Tim SherwoodTottenham suffered a humiliating defeat at Manchester City in November but Manuel Pellegrini's side will expect a tougher test on Wednesday.
Free-scoring City hammered Spurs 6-0 at the Etihad Stadium in November to pile the pressure on former head coach Andre Villas-Boas.
The Portuguese was sacked following another thrashing by Liverpool last month and the appointment of Tim Sherwood has sparked an upturn in fortunes at White Hart Lane.
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Former City striker Emmanuel Adebayor has enjoyed a new lease of life since Villas-Boas' departure, scoring six goals in eight games in all competitions with the new man at the helm.
Tottenham beat City 3-1 at White Hart Lane last season and could do with a repeat performance as they challenge for a top-four finish.
Midfielder Paulinho comes back into contention to face City after missing the last four games with an ankle injury.
England winger Andros Townsend (hamstring) is also set to return to the squad along with Jan Vertonghen (ankle), but Sandro (calf) may not be ready to return and Younes Kaboul (thigh) is also not match fit.
City were given a scare by Championship side Watford on Saturday, but fought back from two goals down at half-time to win 4-2 in the fourth round of the FA Cup.
Pellegrini's title contenders are unbeaten in their last 19 games in all competitions, winning 16 and drawing three.
Tottenham are by no means the only team on the wrong end of a thrashing from second-placed City, who have already scored an astonishing 110 goals in all competitions this season.
Striker Alvaro Negredo, who has scored 23 goals this term, is expected to return against Tottenham after he was not risked against Watford due to a shoulder injury.
The Spaniard is set to continue his partnership with Sergio Aguero, who scored a hat-trick at the weekend to take his tally to nine goals in his last eight games and 25 in total in all competitions.
David Silva (hamstring) is also set to return, while Joe Hart, Pablo Zabaleta, Vincent Kompany and Fernandinho will be expected to start after dropping to the bench against Watford.