Spurs controlled this encounter from start to finish, though they were aided by their guests, who had two players dismissed
The hosts took advantage of their numerical superiority and struck goals from Luka Modric, Jermain Defoe and a brace from Emmanuel Adebayor.
Adebayor would be highly influential for the home side throughout on his home debut, and after just four minutes created an opening that Niko Kranjcar put wide.
Just reward for the positivity shown by Tottenham was soon to arrive, as Modric's searing right-footed drive from 25 yards bent perfectly into the top corner of the net.
Liverpool showed little life, while the diminutive Croatian continued to threaten, soon drawing a save from Pepe Reina with another testing shot.
A surprise break in the one-way nature of the game came when Kyle Walker’s error allowed Andy Carroll to play through strike partner Luis Suarez, whose cool finish seemingly gave Liverpool parity only for referee Mike Jones to correctly blow for offside.
The problems continued to mount up for the visitors as Daniel Agger was withdrawn due to injury, but worse was to come as Charlie Adam, who was already booked, earned a second yellow card for a clumsy challenge.
After the break the pattern continued. Tottenham had all the ball and were in total control of the game, and this advantage was reinforced when yet another yellow card was enough to see Martin Skrtel dismissed.
The space the visitors had to enjoy was perfectly exploited by substitute Rafael van der Vaart, whose probing forward pass to Defoe allowed the England man to run almost unimpeded on goal to score.
The dam had now broken, and Adebayor endeared himself to White Hart Lane a little more when a mistake from Pepe Reina allowed the former Manchester City striker to add to Spurs' advantage.
From there, Tottenham were happy to retain possession and tease their opponents. But they were to inflict one last kick upon their opponents as Adebayor grabbed his second on the final whistle to punctuate a horrible afternoon for Dalglish's side.