The 10-man visitors proved too strong for the group's bottom side, who are left without a point with just one more away match in store
Three second-half goals, two of which came after China had been reduced to 10 men, put the gloss on a solid victory for Jose Antonio Camacho's team.
Despite having the home advantage, it was the visitors who boasted the stronger support, with a sizeable amount of the 5,474 in attendance being Chinese fans.
The first goal did not arrive until four minutes before the break when Chen Tao slipped in Yu Hai to open the scoring.
Singapore nearly found a way back into the game with their first real chance of the night. Aleksandar Duric's shot from close range, after Noh Rahman's low cross had evaded most players inside the penalty box, came off the inside corner of the framework.
But just minutes after that, Li Weifeng doubled his side's advantage as he rose highest to nod home a corner at the far post.
Firdaus Idros again came close for the hosts, who were still looking for only their second goal at this stage of the qualifiers. His toe-poke was just tipped wide as it looked to trickle into the bottom corner of the net.
But seven minutes past the hour mark, China would find themselves a man down as Huang Bowen was given his marching orders for a punch on Mustafic Fahruddin. The Singapore midfielder was also cautioned in the aftermath for kicking out at Huang.
In a mad rush of eight minutes, the visitors still managed to impose their dominance and net two further goals through Zheng Zheng.
The first was a real highlight, as Zheng raced more than half the length of the field before slotting home. Then nine minutes before the end, Zheng capitalised on some more shoddy defending to hit a low shot to the far corner to cap a 4-0 win.