The hosts came from behind in an exciting fixture, with the Liverpool striker's goal cancelled out just one minute later through the former Sevilla forward
With both sides warming up for competitive fixtures the match proved a lively affair, though it was not until the second half that the deadlock was broken. Luis Suarez put the reigning Copa America champions ahead in the 48th minute but Alexander Kerzhakov equalised immediately in what proved to be the final goal.
The game began in an open manner but the hosts enjoyed more of the possession. They looked to make the most of the ball and focused their attacks down the left flank. Despite finding the space they were followed tightly in the centre and failed to forge a chance to shoot.
It was not until the 21st minute that the first chance arose and it went against Dick Advocaat's men. Suarez wriggled into the area after a quick one-two with Alvaro Pereira but after a beautiful piece of skill to beat the defender, he dragged his shot wide.
From then on Uruguay began to assert themselves with a combative midfield performance that limited Russia to playing long balls. In the 26th minute they countered a failed break by the hosts but Edinson Cavani failed to hit the target having been played in on the right of the box by Suarez.
Russia remained a danger on the break though and were playing some impressive passing football. They moved the ball at a high tempo but could not find a route to goal with Roman Shirokov and Pavel Pogrebnyak both thwarted by the opposing defence before the break.
Their lack of productivity saw them fall behind three minutes after the restart as Suarez received the ball wide on the right. He carried it into the box and bided his time with some feigned shots before sending a clinical finish into the bottom corner.
The visitors were only ahead for a minute as a defensive mix-up ended with Diego Godin's clearance being intercepted by Shirokov. He slid a pass to Kerzhakov and the former Sevilla striker lifted the ball past Fernando Muslera and into the net.
Russia were in the ascendancy and Shirokov could have added one himself minutes later when he won possession inside the area but pulled his shot into the side netting.
With the game moving into the closing stages Kerzhakov remained at the centre of the action. Firstly, he saw an effort ruled out in a contentious offside decision and then, with 15 minutes remaining, he was through on goal but overran the ball sending it straight into the arms of Muslera.
It proved to be the last chance of the game and Russia must now turn their attentions to Lithuania who they will face on Tuesday. Uruguay's preparations are over however and they will face Venezuela in a World Cup qualifier on Saturday evening.