The German hosts twice found an equaliser in the first half before Denis Thomalla and a late own goal from Marquinhos condemned Laurent Blanc's men to a 4-2 lossParis Saint-Germain were beaten 4-2 by RB Leipzig in their latest pre-season friendly outing on Friday.
Laurent Blanc's men twice took the lead in the first half, through Hervin Ongenda and Jean-Christophe Bahebeck, but were ultimately punished for some sloppy defending.
Terrence Boyd and Yussuf Poulsen each found equalisers for the hosts, who duly prevailed courtesy of a 65th-minute volley from Denis Thomalla and Marquinhos' subsequent own goal.
In front of a healthy crowd in Leipzig, the hosts - who are preparing to play in Germany's second tier for the first time this season - more than played their part in an open first period.
However, an unmarked Ongenda was left with a simple finish to open the scoring after 10 minutes, having been picked out by Clement Chantome's square ball.
Boyd replied from close range after Nicolas Douchez had made a fine save to keep out Joshua Kimmich's initial header, but PSG - with Zlatan Ibrahimovic featuring from the start - re-took the lead almost immediately as Bahebeck beat goalkeeper Fabio Coltorti to head home a cross from Ongenda.
Ibrahimovic was guilty of a poor miss before Poulsen converted a right-wing corner six minutes after the interval to make it 2-2.
Leipzig then moved in front, Thomalla capitalising on more generosity from PSG's backline, and Marquinhos deflected substitute Stefan Hierlander's effort past his own goalkeeper as Leipzig claimed a notable scalp.
PSG next take on Kitchee in Hong Kong on July 29.