OM, record winners of the Coupe de France, were ultimately undone by a late goal from Ayina, as the minnows progress to the semi-finals
Julien Valero put the minnows into a shock early lead, with a fine finish after just six minutes. The side, ranked 16th in France's third division and who reached the semi-finals in 2010, managed to shut out the ten-time winners for 79 minutes before substitute Loic Remy diverted Andre Ayew's knock-on into the net with five minutes to go to force extra-time.
A frantic extra-time period followed as John-Christophe Ayina netted to put the minnows ahead before Loic Remy made it 2-2 seconds later. However, Ayina would later kill off the game with a minute remaining to eliminate the Ligue 1 side and put Quevilly into the semi-finals.
Didier Deschamps made a few changes from the side that lost to Dijon in the league at the weekend. Gennaro Bracigliano replaced Steve Mandanda in goal, with the former given game time ahead of replacing the France international for the visit of Bayern Munich in the Champions League next week.
Djimi Traore replaced Cesar Azpilicueta, whilst Andre-Pierre Gignac was handed his first start in months for L'OM, with Loic Remy making way. For the amateurs, Zanke Diarra - brother of Marseille's Alou - would go head-to-head against his older sibling.
And it would be Regis Brouard's minnows who would take a shock lead in Caen. A free-kick was deflected in the path of Valéro who swept the ball past the mistaken Bracigliano for the game's opening goal after just six minutes of play.
The shell-shocked Ligue 1 giants instigated a response, and were unlucky not to pull level. Jordan Ayew proved to be a potent threat on the right flank, and his pull-back located the feet of Gignac, whose low effort was heroically blocked by Cedric Vanoukia in front of his own goalkeeper.
L'OM almost equalised through Rod Fanni's header, which deflected off the foot of Alexandre Vardin, and ultimately denied by a sprawling save by Coulibaly, as the third division side entered the interval edging their more illustrious opponents 1-0.
Deschamps attempted to reverse Marseille's decline with the introduction of Remy into action, and his impact told as Quevilly went close through Joris Colinet whose header flew into the side-netting.
Marseille were, in truth well off the pace as Quevilly maintained their attacking play, and actively searched for the game-winning second goal. Pierrick Capelle capitalised on a poor defensive error by Souleymane Diawara, but could not quite direct the ball goalwards, as the visitors were beginning to show signs of fatigue, in what was their 44th game of the season.
For all of the third division side's domination, Marseille would eventually restore parity with five minutes to go. A cross from the right was headed on by Andre Ayew in the path of substitute Remy who helped it into the back of the net, despite Coulibaly's best attempts as L'OM once again saved themselves at the death.
In extra-time, it was Marseille who started at long last to impose their authority on the match, and were almost rewarded as Andre Ayew's effort flew narrowly wide despite good work from Morel.
The tables turned once again however, as Quevilly took advantage of some lax defending from the visitors as substitute Ayina powered a finish past the hapless Bracigliano to take a 2-1 lead after 110 minutes of play. That lead, however only lasted a minute as Marseille exercised their ability to score in tough circumstances.
In a situation akin to Marseille's first, another Ayew knock-on fell into the path of Remy who powered past Coulibaly to level the game again at 2-2.
With two minutes remaining however, Bracigliano would prove to be the villain as he criminally dropped the ball and Ayina took full advantage to wrap up a famous cup victory as the Champions League quarter-finalists bowed out of the Coupe de France.