The Blancos have found life difficult at El Sadar in previous encounters but will be determined to win to keep up the pace with city rivals Atletico and Barcelona at the top
Real Madrid can continue to mount the pressure on La Liga leaders Barcelona when they travel to face struggling Osasuna on Saturday.
Carlo Ancelotti's men have won their last five league games since losing 2-1 to Barca back in October, and sit only three points adrift of the defending champions in third place.However, Real have emerged victorious on only one of their last five visits to El Sadar Stadium in Pamplona and are sure to be tested this weekend.
They will be boosted by the presence of Cristiano Ronaldo, who made a goalscoring return to action in their Champions League clash with Copenhagen after missing the previous three games because of a thigh injury.
France defender Raphael Varane is still out due to a knee injury, while Fabio Coentrao (thigh) and Sami Khedira (knee) remain on the sidelines.
The hosts have endured a dismal campaign so far and sit only one point above the relegation zone going into this game.
Javi Gracia's men have experienced a minor upturn in form in recent times, winning two of their last seven league meetings, but have already lost 10 games and possess the worst attacking record in the division.
Osasuna have scored a mere 11 times in 15 league games, although Gracia would have been pleased with their offensive performance in their Copa del Rey meeting with Malaga last weekend, which ended in a 3-3 draw.
Still, Gracia will have to cope without key midfielder Patxi Punal, who is suspended after receiving a straight red card in their 3-0 defeat to Valencia earlier this month.
Attacking midfielder Nino (knee) is doubtful, with Miguel Angel de las Cuevas (elbow) and Sisi (knee) both unavailable.