The visitors have only conceded twice in the league since their 2-1 win over Hannover in early November and will be tough to overcome for the underdogs
Pep Guardiola's men are well on course to win back-to-back titles, sitting 13 points clear of Bayer Leverkusen after 19 matchdays having dropped just four points all season.
Despite suffering a scare at Stuttgart, when they required two goals in the final 14 minutes to clinch victory, Bayern have begun the second half of the season in much the same way as they ended the first.
Guardiola's side have conceded just twice in the league since beating Hoffenheim 2-1 at the start of November and have scored 19 goals in their last five Bundesliga matches.
Indeed, Bayern have scored as many goals in the top flight this season as strugglers Eintracht Frankfurt, Eintracht Braunschweig and Freiburg combined - finding the net 51 times.
While Nurnberg failed to score against Bayern in two attempts last year, losing 4-0 and 2-0 at the Allianz Arena, they secured a point in the sides' last fixture at the Grundig Stadion in November 2012.
Were Gertjan Verbeek's men to record an unlikely victory, and just their third in the league this season, it would provide a huge boost to their survival hopes.
Currently 15th in the league, Nurnberg could climb as high as 12th with victory but would need a host of other results to go their way.
They will go into the clash with confidence, having won both of their Bundesliga matches in 2014 - overcoming Hoffenheim 4-0 and Hertha Berlin 3-1 - and drawing the three before them.
Josip Drmic will be the man most likely to add to Bayern's tally of nine goals conceded, having scored five times in his last four games.
In what has been a prolific Bayern forward line this season, Franck Ribery and Arjen Robben will pose problems as they continue to approach full fitness after returning from injuries in recent weeks.