Branko Brnovic's side are out to turn their form around as they prepare for the Euro 2016 qualifiers in September
The 2010 quarter-finalists are preparing for a particularly tough group alongside Germany, Portugal and the United States.
Ghana approach Wednesday's friendly in great form, having suffered just one defeat in their last seven games as they lost a penalty shootout in the Africa Cup of Nations final against Libya.
Coach Akwasi Appiah has decided to drop his usual first-choice goalkeeper Fatau Dauda for the trip to Podgorica, with the 28-year-old struggling for first-team football at club level with Orlando Pirates.
Stephen Adams has been selected in Dauda's place and the Aduana Stars man is the only Ghana-based player to be named in the squad, while centre-back duo Jonathan Mensah and John Boye return following injuries.
While the Black Stars are sure to have the World Cup on their minds, Montenegro will use this week's fixture as a chance to make progress ahead of the Euro 2016 qualifiers, which start in September.
Montenegro have been drawn in Group G alongside Russia, Sweden, Austria, Liechtenstein and Moldova, with their qualification campaign beginning against the latter.
Coach Branko Brnovic has labelled Ghana as Africa's leading team and feels Wednesday's match will be of great benefit to his side.
"Ghana is the best team in Africa and they will give us that competitive edge we require in friendly games," said Brnovic.
"Their performance in the World Cup in recent times tells us how good they are as a team.
"They are also preparing for the World Cup and won't come here for fun so we look forward to that game against a very tough opponent."
Although Brnovic believes the match against Ghana will help Montenegro prepare for future competitive action, he will be without arguably his two most important players as Stevan Jovetic (hamstring) and captain Mirko Vucinic (knee) are both unavailable.
Montenegro go into the match having won only one of their last seven matches – a 4-1 friendly triumph over Luxembourg in November.
Their hopes of reaching the World Cup in Brazil were ended by their poor form towards the end of qualifying.
After winning four out of five games at the start of the campaign, Montenegro fell away badly, failing to win any of their remaining five fixtures and finishing a distant third in Group H behind England and Ukraine.