The Reds climbed above Southampton into fifth place with a comfortable win against the out-of-form Magpies, who had Moussa Sissoko sent off for two yellow-card offences
Goals from Raheem Sterling and Joe Allen either side of half-time kept Brendan Rodgers' side's Champions League hopes alive and condemned the Mapies to a fifth consecutive defeat.
To compound the visitors' woes, Moussa Sissoko was sent off late on for two bookable offences.
Following back-to-back league defeats against Manchester United and Arsenal, Liverpool were given an ideal start when Sterling curled home nine minutes in.
Brendan Rodgers' side - shorn of injured striker Daniel Sturridge - controlled the remainder of the half, but were perhaps fortunate not to concede a penalty when Dejan Lovren appeared to foul Ayoze Perez.
While Newcastle improved after the break, Sterling should have put the game to bed before the hour as he conspired to miss from close-range, with Liverpool's profligate finishing frustrating the home faithful.
However, Allen's instinctive strike erased any fears of a slip-up as Liverpool ensured they remain in the hunt for a top-four finish as well as FA Cup honours, with a Wembley semi-final against Aston Villa to come this weekend.
In contrast, John Carver's Newcastle, who saw captain Moussa Sissoko sent off for a second time this season late on, limp towards the end of another disappointing campaign following a fifth defeat on the bounce.
After a dismal showing in the derby defeat to Sunderland, Carver made three changes and Newcastle started relatively brightly prior to the game's first moment of quality that broke the deadlock.
Sterling offered a timely reminder of his prodigious talent as he brought down Jordan Henderson's delivery before breezing past half-hearted challenges from Daryl Janmaat and Gabriel Obertan and curling a strike past the helpless Tim Krul.
The Liverpool pressure was almost constant prior to the half-hour mark, other than a strike from Mehdi Abeid that was comfortably saved by Simon Mignolet.
Newcastle should perhaps have been given an opportunity to draw level seven minutes before the break, but Lovren's clumsy challenge on Perez was not enough to persuade Lee Mason to point to the penalty spot.
Perez had the half's final chance - Mignolet clawing out the Spaniard's header - and Newcastle took that momentum into the second period by creating a flurry of half-chances.
Sterling then missed a gilt-edged opportunity shortly before the hour as he managed to place an effort wide with the goal at his mercy following a defensive howler from Ryan Taylor.
However, as Liverpool got back on top, Mike Williamson's sloppy defending allowed Allen a sight of goal - the Welshman duly firing past Krul to seal the points, with Sterling coming close to a second shortly after.
There was still time for Sissoko - booked for an altercation with Glen Johnson - to cap another disappointing outing for Newcastle by gaining another yellow card for a dangerous tackle on Lucas Leiva seven minutes from time.
It leaves Carver's men looking nervously over their shoulders while Liverpool move fifth.