Made some important catches early on but ultimately to no avail. Could do little to stop any of the goals, although he could perhaps have come for the cross which led to Pandev's goal.
Not a night he'll want to remember. Out-paced and out-muscled by the smaller Higuain for the opening goal and robbed by Mertens for Callejon's clincher.
Performed well early on as he supported Candreva but began to find it tough as Pandev and Insigne grew into the game.
Got forward well in the first half but found himself on the back foot against Callejon more and more as the game wore on. Booked for a rather cynical trip.
Injured his wrist when blocking Insigne's early cross and never really recovered himself. Got forward with gusto but failed to offer much of a threat.
Lazio's best attacking player. He caused Armero no end of problems in the first half and caused the confusion that led to his side's first goal. Faded from the game late on.
Lively in fits and starts for the hosts. Rasped a couple of shots very close to Reina's goal and started a handful of encouraging attacks, but was too often denied space by the visitors' midfield.
Given his lack of football this season, he was a real livewire in the first half, keeping Maggio quiet and creating a couple of good openings. Grew tired in the second half and was replaced.
Alas, poor Lorik. Looked uncomfortable all night long. Out of position for Higuain's opener, failed to clear as Pandev scored the second and fell flat to the floor to allow Higuain his double. Not his finest showing.
Started strongly in midfield but, against the double pivot of Behrami and Inler, he was always under pressure. Unsurprisingly got tired and was replaced in the second half.
Impressive again after his goal against Legia Warsaw last time out, working hard to unsettle Britos and Albiol with his physical presence. His influence waned in the second half.
Commanding in the air throughout, he could do nothing about the first goal or Keita's belter. Not unduly tested otherwise.
A mixed bag for the centre-half. He learned to deal with Perea's physical approach but never looked totally comfortable against the forward bursts of Lazio's attacking midfield quartet.
Did well in the air and made a couple of strong interceptions. Looked suspect at times when Lazio got numbers forward but coped reasonably well with their attacks.
Was torn apart by Candreva in the first half but, to his credit, dusted himself down and performed far better in the second as the hosts began to get desperate.
Kept quiet in the first half, he grew into proceedings and really took control of his flank in the second period.
Scored a comical own goal when he hooked the ball past Reina, but otherwise screened the defence well alongside Inler, working hard to track the runs of Hernanes.
At times deep-lying playmaker, at others combative destroyer, Inler was productive without being exceptional in either role. Helped his side take control of the middle for the majority.
The least effective of his side's attacking foursome, he was nonetheless a useful outlet and caused Konko some problems.
A livewire in attack, particularly in the second half. Worked Radu hard all night and took his goal superbly well late on.
A little outgunned in the first half, he saw more of the ball in the second and used it to full effect. Showed strength and guile to turn and fire home his side's second, and set up Higuain well for his second-half goal.
The undisputed star of the show. His first goal was a sublime show of strength, speed and precision, his second a lethal drive into the corner. Pulled the centre-backs away from their line all night and linked well with his support. A fully-deserved ovation signalled his substitution.