Juve throw away advantage as Champions League ambition is dented by Chievo in dramatic fashion
The legendary captain celebrated his recent one-year contract extension when he scored from the spot just 13 minutes in. Matri then gave his side some breathing space as he stroked the ball nicely into the back of the net soon after the restart.
However, Chievo responded following some slack defending from the home side. Uribe cut the deficit as he scrambled home when the Bianconeri defence fell asleep on a free kick.
Juve's lights then went out completely as the away side came to life when Sergio Pellissier hit the post, but Gennaro Sardo did not miss from close range as he equalised from the rebound.
It was frantic stuff at the Olimpico with constantly alternating fortunes, but in the end the points were shared.
Luigi Del Neri's men started well. Del Piero turned the ball to Fabio Grosso on the flank. The Italian drove into the box in search of Matri, but the Chievo defence scrambled clear.
Chievo were never too frightening for Juve, but sloppy play from Alberto Aquilani allowed Sergio Pellissier a great chance to scare them early as he turned and shot, the veteran was closed down though as Giorgio Chiellini reacted well.
Juventus were dangerous down the flanks and it showed when Pepe was brought down inside the box following a cross from Milos Krasic.
The referee deemed Sardo's pull on his shirt enough to warrant a penalty and Del Piero made no mistake as he hit the top corner to give his side the lead.
It could have been more minutes later when Aquilani tried to chip Stefano Sorrentino from outside the area, but the goalkeeper tipped over the bar.
Juventus were relentless in the approach, limiting Chievo to defending. Aquilani made himself useful again as he started, but couldn't finish a good move.
The on-loan Liverpool midfielder should have buried from just yards out, but he sent Marco Motta's cross woefully over.
Chievo rarely got forward, and when they did it was poor. Bojan Jokic cut inside and curled a right-foot effort towards goal, but Gianluigi Buffon made the save.
Del Piero was simply magnificent as he continued to roll back the years. He was involved in everything by creating, dictating, and leading by example - proving just why the club still believe in him.
Chievo were sleeping at the back, and were lucky not to give away a second penalty. Del Piero fed Grosso who went down, but it was just on the edge of the area.
Del Piero took the resulting free kick and went for the near post, but it was headed clear by Marco Andreolli.
Pepe, the match winner against Lazio last week, almost made his mark when meeting a Krasic cross, but his headed effort was just over.
Motta did fantastically well to get down the line and hold up a ball for Krasic inside the area. The Serbian knocked it back for Matri who turned, only to find Del Piero in his way as the chance was cleared by Andreolli.
Claudio Marchisio stepped up Juve's ambitions when he made his way towards goal. However, his powerful blast was always going to end up behind goal.
However, Matri soon put more space between Juve and Chievo. Del Piero slid the ball into his path before the hitman controlled and buried past Sorrentino.
Chievo appeared dead and no-one would have believed in them getting anything from the game, but Juve's lax approach after going two up backfired badly. Uribe latched onto a free-kick after Gianluigi Buffon failed to save and bundled the ball over the line.
The Bianconeri never recovered from the shock and drifted away as roles were reversed. One minute later, Sardo made up for his earlier error as he smashed the ball into an empty net after Pellissier hit the post.
After that it was an open game with chances flying around at both ends as the teams went for a winner. But, neither side could find it. Luca Toni hit the woodwork for Juve, while Uribe failed to score down the other end after Buffon left his net unguarded. Marchisio cleared off the line to spare the Italy goalkeeper blushes. But, by that point the damage had been done.
A Del Piero free kick always looked promising, but it ended up over the bar in the final minutes.
It's a poor result for the Old Lady of Italian football, who had dominated all areas until gifting Chievo a lifeline.