The Nerazzurri were comprehensively dismantled by their visitors' effervescent display, who secured qualification for the Europa League in style
After surging to fifth in the table on the back of seven consecutive wins, all the Zebrette needed were three points to secure themselves European qualification for the third time in a row, and goals from Giampiero Pinzi, Maurizio Domizzi, Antonio Di Natale, Gabriel Silva and Luis Muriel set them on their way in spectacular fashion.
Inter coach Andrea Stramaccioni had to contend with his side's ongoing injury crisis, and his misery was compounded when, not a minute in, Allan fed Pinzi for the midfielder to leave Juan Jesus standing and rifle home past Samir Handanovic.
Juan attempted to redeem himself by blasting in Inter's first shot of the night, which Zeljko Brkic got down well to parry, but right after, Di Natale stole in undetected to connect with a deep cross, leaving the hosts thanking Esteban Cambiasso for his timely intervention off the line.
But from the ensuing set-piece swung in by the Udinese captain, Domizzi rose highest in the area to head home and double his team's advantage in the ninth minute, breaking the San Siro's spirits.
The Nerazzurri were not ready to roll over just yet, however, and a penalty area rebound allowed Juan to stab home for his debut Serie A goal. Tommaso Rocchi then conspired to miss Inter's equaliser, firing a well-weighted Alvaro Pereira pass wide.
Handanovic next denied Di Natale after the 35-year-old was put through by Dusan Basta's sumptuous pass, with the Slovenian mightily standing his ground to thwart his former team-mate.
Di Natale was not to be denied though. As Udinese piled forward on the brink of half-time, the evergreen striker produced a moment of magic by curling off the far post to take the wind out of Inter's sails and prompt the crowd to its feet in grudging applause.
The second period brought no respite for Strmaccioni's men as Muriel produced a magnificent run from deep to feed Silva, the Brazilian obligingly dinking neatly over Handanovic. Rocchi next compounded Inter's slump by hitting the post after good work by Fredy Guarin.
Substitute Rodrigo Palacio's squared pass nevertheless allowed Rocchi something to show for his efforts, with the January arrival firing home before being replaced himself. But even that was not enough to stem the Udinese tide, as a defensive mix-up between Yuto Nagatomo and his keeper allowed Muriel to capitalise on a loose ball and roll it into an empty net, completing the rout.
Stramaccioni's dismal end to the campaign leaves his position untenable despite receiving support from president Massimo Moratti earlier this week, as Inter prepare to contend in the Coppa Italia play-offs in August after finishing a woeful ninth.
However, there was no such heartbreak for Udinese with their stunning victory wrapped up, as the Fruili outfit were left to dream of rubbing shoulders with the continent's elite once again.