Rudi Garcia's side are yet to taste anything other than victory in Serie A but face a stern test against the resurgent Nerazzurri
Rudi Garcia's side have won all six of their league outings so far this term, conceding just one goal in the process, but their hosts are also unbeaten.
Walter Mazzarri has guided his men to four wins and two draws so far, a run that leaves them fourth in the table, four points behind the Giallorossi.
Under the stewardship of Andrea Stramaccioni, Inter struggled to a ninth-place finish in Serie A last summer, and even though they appear to be on the right track after a close-season of upheaval, they are not thinking about a title tilt - not just yet, anyway.
As well as boasting the division's meanest defence, Roma are also the Italian top-flight's leading scorers, with 17 goals.
Inter, meanwhile, followed up a commendable win over Fiorentina with a draw at Cagliari and they go into the weekend in good form.
Roma's recent record in this fixture gives them the edge, having won four and lost none of their last six meetings, an undefeated streak that includes two victories at San Siro last season.
In stark contrast to their 2012-13 campaign, though, Inter have not been beset by injuries thus far this term, while they are seeing key players, such as forward Diego Milito, return from lengthy spells on the sidelines.
However, defender Christian Chivu (foot) is expected to miss another few weeks of action and club captain Javier Zanetti (Achilles tendon) could be out until December.
Garcia has a few more injuries to contend with, though. Adem Ljajic (sciatic nerve) is doubtful, while Maicon (thigh), Michael Bradley (ankle) and Mattia Destro (knee) will definitely not be involved.