The veteran trequartista created goals for Alessandro Florenzi and Pablo Osvaldo, before Marquinho sealed a fine win for the Giallorossi with his late strike
Francesco Totti was the star of the show at San Siro, setting up Alessandro Florenzi for the opener before creating a second for Pablo Osvaldo - who was sent off late on for a second bookable offence - after Inter had drawn level with a deflected effort from new boy Antonio Cassano.
The Giallorossi then put the seal on a fine win when substitute Marquinho, who had come on during the first half for the injured Daniele De Rossi, fired home with just under 10 minutes remaining.
Inter, high on confidence after last week's encouraging win at Pescara, handed a first Serie A appearance to Alvaro Pereira and the former Porto man was one of the key protagonists of an absorbing first half, offering the hosts tremendous width on the left hand side - even if his crossing was incredibly erratic.
However, it was Florenzi - also making his first start in Italy’s top flight - who opened the scoring at the Giuseppe Meazza.
The 21-year-old midfielder made a splendidly timed run into the area to meet Totti’s inviting cross from the left wing, with an perfectly-placed header that gave Nerazzurri goalkeeper Luca Castellazzi no chance.
With Zdenek Zeman’s side holding a predictably high line, Diego Milito repeatedly threatened to break the offside trap, but the Argentine’s most clear cut goalscoring opportunity came courtesy of a delightful outside of the foot ball into the area from Wesley Sneijder. The Argentine managed to get ahead of Federico Balzaretti and connect with the cross, but his header flashed wide.
However, Inter did eventually draw level courtesy of another measured pass from Sneijder. The Dutch playmaker released Cassano in injury time at the end of the first half and the former AC Milan man cut inside Leandro Castan before unleashing a shot that took a wicked deflection off Nicolas Burdisso, the ball clipping the Argentine’s heell before looping over a helpless Maarten Stekelenburg and into the Roma goal – via the right post.
The hosts, though, failed to build on that strike after the interval and Osvaldo had already fired two shots wide before he deservedly put Roma back in front with a deft chip over the advancing Castellazzi, with Totti the supplier again.
Inter tried to rally but Marquinho effectively ended the game as a meaningful contest after he half-volleyed home from an acute angle following Osvaldo's measured pass.
Indeed, even though Osvaldo saw red for a needless handball late on, Roma saw the game out with relative ease in a performance that suggests Giallorossi look better equipped to challenge for the Scudetto this season than Andrea Stramaccioni's Nerazzurri.