Roma looked to be cruising at 3-0 up but they did not reckon on a stunning, spirited fightback from Genoa.
Genoa produced an incredible fightback to defeat Roma, despite trailing by three goals at one stage. Argentine striker Rodrigo Palacio turned in a virtuoso performance in the second-half as the Roma defence collapsed under the pressure of hosts who looked to be dead and buried by the hour mark.
The Giallorossi made the perfect start, seemingly showing no ill effects from their Champions League defeat at home to Shakhtar in midweek. French defender Philippe Mexes, who was returning from a two-game ban, headed home from a Francesco Totti corner to give the home side the lead in the sixth minute.
Four minutes later, the visitors suffered a blow when Simone Perrotta was stretchered off with an injury after being hurt in a robust challenge. Roma were not overly troubled, though, and they proceeded to double their advantage on the quarter-hour. Nicolas Burdisso was the beneficiary from an excellent Totti free-kick as the Genoese defence were found wanting.
Roma looked to have built up an impregnable cushion when they scored their third five minutes after the break. Mirko Vucinic was too hot to handle for the Genoa defence and his sterling work set up Totti at the back post. Kakha Kaladze was powerless to prevent the veteran attacker from finding the bottom corner with a cool left-footed finish.
Almost instantly, Genoa got a goal back - although few could have anticipated what was to follow. Roma goalkeeper Julio Sergio came off his line to avert danger but only succeeded in scooping the ball into the path of Rodrigo Palacio, who did not look a gift horse in the mouth, slotting home into the vacant goal.
Substitute striker Alberto Paloschi then got in on the act. The youngster was left unmarked inside the penalty box and he found the back of the net with a fine left-footed finish on 68 minutes to reduce the arrears to just one goal. By now, Roma were crumbling and parity was achieved six minutes later thanks to Palacio's deft header at the back post, which eluded Julio Sergio.
Given the momentum of the game, there was no reason why Genoa needed to settle for the point. They completed an astonishing comeback with a mere five minutes remaining. Domenico Criscito threaded the ball through for Palacio, whose pace took him to the by-line. He cut the ball back towards the centre, where Paloschi was waiting to tap the ball home.
Genoa's stunning victory lifts them into tenth spot on 35 points, four behind eighth placed Roma. Genoa travel to Catania next week whilst Roma host Parma.