The Grifone have lost just one of their last 10 league fixtures at home but Antonio Conte's men are likely to be buoyed by the return of Carlos Tevez
Genoa believe they can cause one of the upsets of the Serie A season by defeating runaway leaders Juventus on Sunday.
The Grifone should enter the match fresher after the Bianconeri were held to a 1-1 draw by Fiorentina in the opening leg of their Europa League last-16 tie on Thursday.
Gian Piero Gasperini's side did not have to play in midweek and will have been encouraged by the Viola's fighting display against the reigning champions.
The underdogs will also take heart from their excellent home record, which has seen them lose just one of their last 10 Serie A fixtures.
A 2-1 defeat at Chievo last week ended a four-match unbeaten run, but Genoa's Luca Antonelli remains hopeful, despite acknowledging the size of the task.
"We will try to make the impossible possible," the defender is quoted as telling the club's website ahead of the home match.
"The difference between the two sides in terms of value and our positions in the table is clear.
"[But] there is a fantastic vibrancy around the place and that could help us stop the Bianconeri."
Genoa defensive duo Sime Vrsaljko and Alessandro Gamberini will miss through injury, while Juraj Kucka, Luca Antonini and Antonio Donnaruma are also expected to be absent. Ghanaian Isaac Cofie is suspended.
Alberto Gilardino is available for selection, though, and the former AC Milan forward has netted 12 goals in 26 league matches this season.
Juventus, however, have only lost once in Serie A this season and lead the second-placed Roma by 14 points.
Antonio Conte will ask his side for a response after their disappointing draw on Thursday and his side are in great league form.
They have won their last four Serie A encounters, conceding just one goal in the process, and beat Genoa 2-0 in Turin in October.
France midfielder Paul Pogba has been one of the club's key men this season and said Conte has stars to pick from in every position.
"What's special about Juventus? Excellent players, like [Gianluigi] Buffon, [Andrea] Pirlo, [Arturo] Vidal," Pogba said on Friday.
"I'm happy to play alongside so many world-class names. They're the best in Italy and I need to learn from them if I'm to follow in their footsteps and reach the very top."
Pirlo will return from a one-match Serie A suspension for Juve, who are likely to recall Carlos Tevez, with the Argentine not featuring against Fiorentina on Thursday.