The Serie A titleholders need only a point to qualify for the knockout stage but will face a typically hostile reception in Istanbul
However, while Antonio Conte's men have just one win from five Group B fixtures so far, three draws sees the Serie A champions occupy the second qualifying spot behind Real Madrid, two points ahead of their hosts, meaning a draw would be good enough for the Bianconeri to progress to the knockout stage.
Furthermore, the Italians have been on an impressive run of form of late and are unbeaten in nine matches in all competitions.
That said, Gala's nine-game unbeaten home record against Italian opponents will be a cause of some concern for the men from Turin.
Galatasaray coach Roberto Mancini - a boyhood Juventus fan - took charge of the Turkish champions for the first time in the reverse fixture on October 2 and has a record of five wins, nine draws and five defeats against the Old Lady as a coach.
The matchday two fixture between these sides ended 2-2, with Didier Drogba putting the visitors ahead before late goals from Arturo Vidal and Fabio Quagliarella appeared to have given the Serie A titleholders the three points - only for Umut Bulut to fire home two minutes from time to snatch a draw.
Drogba has history when it comes to eliminating Juventus from the Champions League, scoring in both games as Chelsea beat the Serie A club 3-2 over two legs in the round of 16 in 2008-09.
The most significant piece of team news is the absence of Bianconeri playmaker Andrea Pirlo, who is set to be out until next month with knee ligament damage, though Galatasaray will be without long-term absentee Hamit Altintop.
Speaking after his side's 4-1 defeat against Madrid a fortnight ago, Mancini said of the qualification showdown with Juve: "We will definitely need the support of our fans.