The west London club have been in excellent form, unbeaten in the league since the start of December, while the Hammers have not won at Stamford Bridge since 2002
Jose Mourinho's men currently share a run of five consecutive league victories with leaders Arsenal, while second-placed Manchester City have won seven in a row, meaning just two points separate the sides in the race for the title.
Chelsea should be full of confidence ahead of Wednesday's meeting with a West Ham side who have just one win from their last nine fixtures in all competitions.
|5/2||Chelsea are 5/2 with Betway to win the title this season|
Frank Lampard scored a double against his old club on that occasion, breaking the deadlock with a 21st-minute spot-kick before finding the net again late on after Oscar had doubled the advantage.
Chelsea marked Mourinho's 51st birthday with progression to the fifth round of the FA Cup on Sunday, while West Ham should be fresh having had a weekend off after being eliminated by Nottingham Forest in the third round.
And West Ham manager Sam Allardyce knows the magnitude of the task that lies ahead of his side, who are third bottom in the Premier League.
"Stopping Oscar, [Eden] Hazard, [Samuel] Eto'o is one of the elements for us which we have to be very careful of," he said. "When those players get the ball we have to make sure we're very sharp and that we close them down, otherwise their skills and abilities will make life difficult for us."
Fernando Torres (knee) remains sidelined for Chelsea, while Nemanja Matic could be given his first league start since he returned to the club from Benfica. Mohamed Salah, who signed from Basel on Sunday, is not expected to be available.
Allardyce, meanwhile, has a near fully-fit squad to choose from, with former Chelsea midfielder Joe Cole and Winston Reid the only players guaranteed to miss out.
As well as his returning players, Allardyce's ranks will be boosted by the arrivals of new signings Marco Borriello and Antonio Nocerino, who could go straight into the squad for Wednesday's match.