There were no goals for either Cagliari and Sampdoria in a lacklustre match.
Prior to the match, Sampdoria coach Domenico Di Carlo confirmed the club had decided to rest star Antonio Cassano due to the amount of matches he had played in the last month for both club and country.
Cagliari had the better of the opening minutes, as Andrea Cossu swung a dangerous ball from the left looking for Robert Acquafresca, but Luciano Zauri read the play and headed the ball away.
Both teams struggled to find space, with the first chance of the match falling to Daniele Dessena on 12 minutes. Making a timely run into the box, he almost got his foot to a loose ball, but Alessandro Agostini managed to clear it away.
Angelo Palombo earned a free-kick nine minutes later for the Blucerchiati from 40 yards out on the right flank, and looked to find Nicola Pozzi at the back-post. The young striker tried to square his header, but could only direct it into the hands of Michael Agazzi.
Giampaolo Pazzini and Pozzi combined 60 seconds later when the latter controlled the ball and laid a pass off for the Italian international in front of goal, but his rifling left-foot shot from 30 yards went just wide of the right post.
A great chance fell to Acquafresca five minutes from half-time, as the striker rose above the pack to meet Agostini's cross from the left, but couldn't keep his header down.
The away side started the better in the second half, as they tried to make up for a dismal first 45 minutes, looking to attack more and break the deadlock. They were rewarded with a free-kick on 53 minutes when Pazzini was brought down by Astori on the right. Reto Ziegler stepped up and fired a low shot, straight into the hands of Agazzi.
Four minutes later, Nene managed to find the back of the net, but it was chalked off for the striker being offside.
Pazzini took things into his own hands not even a minute later when he decided to fire a long-range, dipping shot from 30 yards, but it didn't come down enough, going just over the crossbar.
The best chance for Sampdoria came with 10 minutes to go in the match, when Pazzini almost rounded Agazzi, but the 'keeper managed to get a fingertip to the ball, and divert it off course.
The fourth official added three minutes of injury time, but neither side could find the back of the net.