The Italian champions will be aiming to pick up momentum after the international break...
Cagliari are one of the also-rans in Serie A and given the competitiveness of the Italian top flight, the side from Sardinia could very well struggle against the drop at the end of the season.
At the moment Pierpaolo Bisoli's side are in the bottom half of the league table with seven points from six matches, just two more than third-from-bottom Parma. Club president Massimo Cellino is becoming increasingly frustrated with the Isolani's lack of results in the league and there are reports that former Italy and Napoli tactician Roberto Donadoni could replace Bisoli if the situation doesn't improve.
However, the positive for Cagliari is that they have yet to lose at home in the league this campaign and have also scored five times in two matches at the Stadio Sant'Elia and have conceded just one.
Inter began their 2010-11 campaign on a slow note but the Italian and European champions are now in full swing and are looking very threatening indeed. Rafael Benitez's side bounced back from their 1-0 defeat to Roma in Rome to hammer Werder Bremen 4-0 in Milan in the Champions League, and just before the international break drew 0-0 with Juventus.
At the moment Inter are second in the table with 11 points from six matches, just two behind Lazio. The Beneamata will aim to leapfrog the Aquile, who are not in action until Sunday evening.
Inter have lost just once in the league this season but that defeat came on their travels, so Benitez's side will have to be wary of getting too complacent during their lunchtime kick-off.
Ragatzu is out with an injury for the Sardinians, who will opt for a 4-3-1-2 system that will have Matri and Acquafresca as the two strikers and Cossu as the creator-in-chief just behind them.
Rafael Benitez will be without Mancini, Cordoba, Milito, Cambiasso, Mariga, Suazo and Pandev, all of whom are injured. Thankfully for the Spaniard, Sneijder is fit to start. Thiago Motta has been passed fit too but the midfielder will be a substitute.