Jurgen Klopp, who is set to become his club's longest-serving coach, could be without 10 first-team players for the game at Signal Iduna Park
Borussia Dortmund are braced for a difficult start to the Bundesliga season in what will be landmark clash with Bayer Leverkusen for their current coach.
BVB boss Jurgen Klopp will become his club's longest-serving coach when he takes charge of Saturday's game at Signal Iduna Park, having been at the helm since 2008.
The charismatic 47-year-old tactician is set to break Ottmar Hitzfeld's record tenure at Dortmund and there will be a sell-out crowd to mark the occasion for a mouth-watering first league game of the 2014-15 campaign.
Dortmund finished 19 points adrift of champions Bayern Munich last season and have since lost striker Robert Lewandowski to their Bavarian rivals.
However, the club have added Adrian Ramos and Ciro Immobile to their ranks to replace the Poland striker and will be buoyed by their 2-0 DFL-Supercup success over Pep Guardiola's men last week.
On the injury front, Nuri Sahin (knee) is closing in on a return, but the game is expected to come too soon for the midfielder.
Oliver Kirch (thigh) and Ji Dong-won (hamstring) will play no part after sustaining injuries in training this week, but Erik Durm (illness) should be available.
Lars Bender could make a welcome return for the visitors after recovering from a thigh injury, while Kyriakos Papadopoulos is also in contention to make his debut following his loan move Schalke.