The two-time Serie A champions are in fine form, but will have to do without Andrea Pirlo, who is set for a spell on the sidelines with a knee injury
The Turin outfit - who have won back-to-back Serie A titles - head into the fixture at the Stadio Renato Dall'Ara on a run of six straight league victories, a streak that has taken them three points clear of second-placed Roma.
Juve's latest success came in a 1-0 triumph over Udinese on Sunday, with Spain international Llorente notching the only goal of the game in second-half injury time.
The 28-year-old joined Antonio Conte's side from Athletic Bilbao in the close-season and initially struggled for form, but now appears to have found his rhythm having scored in Juve's last three league games.
The champions have dropped only five points in Serie A this campaign, tasting defeat just once in 14 games in a 4-2 setback to Fiorentina on October 20.
But Conte was dealt a blow before the showdown with Stefano Pioli's men, with the news that playmaker Andrea Pirlo is set for an indefinite spell on the sidelines with a knee ligament injury.
In contrast to Juventus' flying start, Bologna languish in 17th position and suffered the humiliation of being knocked out of the Coppa Italia by Serie B outfit Siena on Tuesday.
Only newly-promoted Sassuolo have conceded more than their 26 goals in 14 outings, and they have not beaten Juve at home in their last nine attempts.
Pioli's team are also on a four-game run without victory in Serie A, and have won just two of their last 15 top-flight fixtures.