Bayern Munich lost 2-0 to Inter on November 23, 1988 in the UEFA Cupwhich is tied for their heaviest home defeat in European action.
Mario Gomez leads the team in scoring with seven goals in the Champions League including the late strike against Inter in the first leg at San Siro.
Die Roten's overall home record against Italian teams is: W 6, D 5, L 4.
In 20 UEFA competition ties in which they have won the first leg away, Bayern have advanced to the next round.
Bayern have won all three of their previous penalty shoot-outs in UEFA club competitions.
Inter striker Samuel Eto'o also has seven goals in the competition, one behind Lionel Messi at the top of the scoring charts.
Diego Milito and Thiago Motta have been ruled out of the crunch clash through injury while Lucio is unlikely to feature as well.
Facing German opposition on foreign soil, Inter's record is: W 4, D 7, L 4.
Inter beat Bayern in last year's final and have avoided defeat in their last two visits to Munich.
The Nerazzurri signed 18-year old talent Christoph Knasmuellner from Bayern in January. The Austrian is not in Inter's Champions League squad, however, and will miss the game.
February 23, 2011: Inter 0-1 Bayern Munich
Bayern goalkeeper Thomas Kraft stood tall and proud between the sticks until the Bavarians were able to capitalise on one of their many chances late in the game. Arjen Robben's low drive was spilled by Inter shot-stopper Julio Cesar and Mario Gomez was on hand to pounce on the rebound in injury time, giving the Germans a one-goal advantage heading into to the second leg at the Allianz Arena.
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The 30-year-old will have to be at his best on Tuesday if the defending champions hope to defend their title. He was a nuisance in the first leg and will need to find the back of the net if Inter are to advance to the next round.
After both teams spurned a plethora of scoring chances in the first leg, expect a lot of fireworks at the Allianz Arena on Tuesday evening. The onus will be on Inter to attack from the opening whistle and Leonardo's men will overturn their first-leg deficit thanks to the heroics of Samuel Eto'o.