Jose Mourinho saw the Switzerland side defeat his team at Stamford Bridge in the opening fixture of the group and will be looking to avenge that surprise resultChelsea can secure qualification for the Champions League knockout stage should they avoid defeat against Basel on Tuesday evening.
Jose Mourinho's side sit at the top of Group E with nine points, three clear of second-placed Schalke and four ahead of their Swiss opponents.
Chelsea suffered a surprise defeat against Basel at Stamford Bridge on September 18 but have since won all but three of their 13 games in all competitions since that result.
Mourinho's men head into Tuesday fixture following a comfortable 3-0 victory over West Ham as Frank Lampard scored twice against Sam Allardyce's side, while Oscar also netted.
David Luiz (knee) has not travelled with the Chelsea squad, although Fernando Torres will return to contention having recovered from a recent adductor injury.
Ashley Cole (rib) may be fit enough to challenge Cesar Azpilicueta for a srtarting spot, having been an unused substitute on the weekend.
Apart from Marco van Ginkel (knee), Chelsea have no long-term absentees, and they will be eager to avenge an embarrassing home defeat in September.
Basel top the Swiss Super League by three points after coming from behind to beat Thun 4-1 on Saturday, with Marco Streller – who has now scored nine times this season – getting on the scoresheet.
They are unbeaten in their last eight matches and are in terrific form on their travels, undefeated in all 15 games on the road in the current campaign.
Both of their losses this season have come at home and they will be without Chile midfielder Marcelo Diaz, who suffered a rib injury while on international duty.
Behrang Safari (thigh) will also miss out when Basel look to complete an unlikely double against formidable opposition.
They are unbeaten in their last four Champions League matches against English sides, including a famous 2-1 win over Manchester United in December 2011 that saw their opponents fail to qualify from the group stages.