Arsenal have lost their past two home league games and are looking to avoid losing three in the Premier League on home turf for the first time in their history.
Arsene Wenger's men won three league matches in November, but all those victories came away from home as they lost to both Tottenham and Newcastle United at the Emirates.
However, the Gunners should take heart from the fact that they have never lost to Fulham in the league in the sides' 23 previous meetings. Arsenal have won 20, whilst three matches have been drawn.
Cottagers aiming for only third win of season
Fulham currently find themselves sitting second bottom in the Premier League with Mark Hughes overseeing only two wins since taking over as manager from Roy Hodgson in the summer.
The Cottagers' goalkeeper Mark Schwarzer will be making his first appearance against the club who tried to buy him in the summer and will want to put in a good performance at the Emirates to show the home support what they are missing.
Fulham will be hoping to show a greater attacking threat than they have in their last three meetings with the Gunners where they have failed to score a single goal.
Arsene Wenger has confirmed French pair Samir Nasri and Sebastien Squillaci will be available for selection despite both players being doubtful earlier in the week with knee problems.
However, the Gunners will still be without captain Cesc Fabregas (hamstring), Abou Diaby (ankle) and Thomas Vermaelen (achilles).
Goalkeeper Manuel Almunia will also miss the games with an elbow injury.
The north London club have an abundance of talent in attacking positions and Wenger must decide whether to retain Robin van Persie in the starting line up, or go with Marouane Chamakh.
Possible starting XI: Fabianski; Sagna, Squillaci, Koscielny, Clichy; Song, Wilshere; Nasri, Arshavin, Walcott; Chamakh.
Andrew Johnson is fit and available for selection following the hamstring strain that saw him miss last weekend's draw with Birmingham City.
However, Mark Hughes' injury list is still very long and he is without Moussa Dembele (ankle), Rafik Halliche (thigh), Carlos Salcido (ankle), Philippe Senderos (Achilles), Fredrik Stoor (groin) and Bobby Zamora (leg) for the trip to the Emirates.Possible starting XI: Schwarzer; Baird, Hangeland, Hughes, Kelly; Davies, Murphy, Etuhu, Dempsey; Gera; Kamara.