The Ligue 1 leaders eventually booked their place in the last 16 of the Coupe de France against the minnows, but also saw their Argentine star limp off in the first half
A Nene penalty put the capital club ahead in a somewhat turgid first half, before Kevin Gameiro doubled the lead after the hour. Further efforts from the duo late on ensured progression for the eight-time winners. Sable, for all their hard work, could only trouble the visitors through long-range efforts, notably from Arnaud Lisembart.
Carlo Ancelotti fielded a strong line-up, with only four changes to the side that swept away Toulouse 3-1 in the league last weekend. Kevin Gameiro returned up front, along with Ceara, Clement Chantome and Zoumana Camara.
Nevertheless, it was their less-esteemed hosts who raced out of the starting blocks first after a minor defensive mix-up. Yoni Journet slipped in between Camara and Mamadou Sakho, before forcing Salvatore Sirigu into an early stop.
Les Parisiens, who at this point looked sloppy on the ball, and failed to muster any clear-cut chances against Sable, were dealt a blow midway through the first half. Javier Pastore, under pressure, looked to have injured his left thigh, and was to be duly replaced by Christophe Jallet.
The Ligue 1 leaders stepped up the ante, but were largely thwarted by a resolute home defence. Nene found space down the right flank, before initiating a lofty ball in towards Kevin Gameiro, who couldn't control as it bobbled harmlessly toward goalkeeper Antony Sybille.
Sable's defence was to be opened up as Gameiro narrowly missed with his powerful half-volley from Mamadou Sakho's header. The initiative was with PSG, who were awarded a penalty soon after Nene was hacked down in the box.
The Brazilian consequently side-footed his penalty past Sybille for his 12th goal of the season to put Ancelotti's men 1-0 ahead at the interval in an uninspiring first 45 minutes.
Gameiro almost doubled his side's advantage early into the second half. Calmly latching onto Nene's through ball, the France international out-paced his marker before his powerful shot was palmed away by Sybille. Seconds later, Nene's effort from Jallet's pullback was also to be thwarted by the inspired keeper.
Olivier Pignolet's charges enjoyed their phase of domination, but couldn't manoeuvre a way past their visitors. Firstly, Emmanuel Thibault was fed a sweeping ball, but after buckling under the challenge of Gameiro, referee Anthony Gautier refused to give a penalty. The hosts nearly equalised soon after as Sirigu almost allowed in a sumptuous 35 yard strike by Arnaud Lisembart.
Les Parisiens were looking more likely to hit on the counter as Sable upped their attacking tempo, and it almost paid dividends as Gameiro ran clear, only to be thwarted again by Sybille.
Sable's luck had run out, and were to concede again despite their gallant efforts. Nene cut through a mismatched defence and laid off Jeremy Menez, who bamboozled his marker and Sybille by side-footing for Gameiro to tap into an empty net on 65 minutes.
It was to be 3-0 nine minutes later, as Gameiro slipped in behind the defence finishing off another assist from Nene to make it 14 goals for the campaign and eventually put the tie out of reach. Nene wrapped up the victory by scoring in injury time, before being denied a potential hat-trick with another Sybille save.
Following their cup win, Carlo Ancelotti's side become the first side to reach the round of 16 of the Coupe de France. PSG resume their Ligue 1 campaign away to Stade Brestois next Saturday.