The Sinsheim outfit are facing an injury crisis with five players from the first team ruled out from the Bundesliga clash against the defending champions. Defenders Manuel Gulde and AndreasIbertsberger, midfielders Tobias Weis and Boris Vukcevic as well as striker Vedad Ibisevic have been deemed unfit to start the game on Saturday.
Hoffenheim record transfer Gylfi Sigurdsson and defender Matthias Jaissle are set to recover from injuries by Saturday, but are unlikely to start the match against Dortmund.
Jurgen Klopp will have to do without the services of first-choice striker Lucas Barrios, who is out for at least four weeks after picking up an injury while on international duty. Defenders Patrick Owomoyela, Neven Subotic, Julian Koch are also set to miss out on the clash against Hoffenheim as they are still recuperating.
Germany international Marcel Schmelzer is expected to recover in time for the game, but is unlikely to start the match.
DID YOU KNOW?
Hoffenheim have lost just once in their six Bundesliga games against the reigning champions.
There have been four dismissals and three penalties in the seven competitive matches between the two teams.
Hoffenheim lost their Bundesliga opener for the first time in their history last Saturday.
Borussia Dortmund won against every team last season, except Hoffenheim, on their way to their seventh Bundesliga title.
Germany international Mario Gotze, who played a key part in the national side's win over Brazil on Wednesday, has been in scintillating form so far, and was involved in all three goals Dortmund scored in the Bundesliga opener.
Kevin Grosskreutz recorded his first double last Friday.
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The Ghana international will have to be on the top of his game if Hoffenheim are to keep Dortmund at bay on Saturday. The centre-half will be burdened with the task to keep Gotze & co. at bay, which is a herculean task these days.
The new prince of German football is expected to dazzle once again on Saturday, and will be looking to add to his Bundesliga tally against Hoffenheim. Based on his showing against Brazil, Gotze is set to give another majestic performance in Sinsheim.
The Bundesliga champions traditionally have problems against Hoffenheim, but are in great form and will be expected to improve their record in Sinsheim on Saturday. Holger Stanislawski's men will put up a fight, but will most likely lose out to Borussia Dortmund.