It remains to be seen whether new coach Claudio Borghi will continue in the same vein as his predecessor Marcelo Bielsa in regards to his approach to national-team matters. However, what is for certain, is that he will use the crux of the squad that represented the nation at World Cup 2010. The likes of Alexis Sanchez and Arturo Vidal will strive to boost their burgeoning reputations with good showings at this year's tournament.
Mexico's award-winning 4-2-3-1 will once again be adopted for the Gold Cup winners, after a hugely impressive 4-2 victory in the final against the United States. However, coach Jose de la Torre has decided to opt for a very young and inexperienced side, dropping many of his most trusted lieutenants such as Carlos Vela, Carlos Salcido and Javier Hernandez. Rafael Lugo is thus expected to lead the line for the Mexicans in the absence of his first-choice compatriots.
Chile are one of three South American teams to have never won Copa America, along with Venezuela and Ecuador.
They have failed to progress beyond the first round on four of the last eight occasions.
Progress is being made though, as they were quarter-finalists last time round, and finished in the last 16 of World Cup 2010.
Chile have been in impressive form since last summer, being unbeaten in six matches, including a comfortable 2-0 win over Copa rivals Uruguay.
Mexico have never won Copa America since their invitation in 1993, although they have come runners-up twice in 1993 and 2001, whilst finishing third place on three occasions.
They successfully defended their Gold Cup trophy, after beating the United States 4-2, sending them also to the 2013 Confederations Cup.
Mexico have been in fantastic form throughout 2011, winning all six Gold Cup fixtures and losing just once in eight matches prior to their cup success.
They are unbeaten in their three meetings with Chile, winning two and drawing one of them, with the last coming in May 2010 in an international friendly.
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The stage is all set now for the Chilean talisman to win the plaudits and receive critical acclaim for his opening bow in this year's Copa America. The likes of Messi, Neymar and Falcao have failed to inspire their respective nations thus far, so it will be Sanchez's turn to show them all how it's done and steal the show.
The former Barcelona starlet has had a turbulent club career since leaving Catalunya for North London in 2008, but regarding international matters, he has been simply electric at times for Mexico. His delightful goal in the Gold Cup final will live long in the memory, but he is hoping to quickly replace that with yet more virtuoso displays in Argentina. Despite being just 22, he already has 45 caps to his name and goes into this tournament as his country's most experienced player.
Chile possess one of the tournaments brightest and most talented pool of players, and this coupled with Mexico's decision to blood the squad with a number of unproven and inexperienced players from the Primera Division means there should only be one outcome - a convincing Chilean victory. However, the likes of Dos Santos and Barrera may penetrate the Chilean defence and exploit the flanks, so it should make for a fascinating encounter.