Gonzalo, Xavi Olivia and Angel Lopez are Villarreal's three long-term injury casualties. Juan Carlos Garrido has no other concerns, with veteran midfielder Marcos Senna expected to keep his place in the starting XI after having just returned from his own lengthy lay-off.
Real Madrid (4-2-3-1) Adan; Sergio Ramos, Pepe, Carvalho, Marcelo; Alonso, Lass; Di Maria, Ozil, Ronaldo; Higuain
Sergio Ramos returns from suspension while Kaka is expected to also be recalled to the matchday squad after being rested in midweek against Getafe to nurse a muscle strain. Sami Khedira has recovered from his leg injury but it is yet to be determined if he is match fit to play any part against Villarreal.
DID YOU KNOW?
Villarreal have secured a place in next season's Champions League play-offs. If they qualify for the tournament-proper, it will be their third season in the competition.
Juan Carlos Garrido's men have won just three of their last 10 league games.
The Yellow Submarine have only ever emerged victorious in two of their 23 meetings with Madrid in La Liga.
Villarreal's leading goalscorer this season is Giuseppe Rossi with 18 goals. Their leading assist man is Santi Cazorla with 10 assists.
Real Madrid will finish second in La Liga this season, but they will not be able to match their points tally (96) from last term. They are also 11 goals shy of their 102-goal haul under Manuel Pellegrini.
Los Blancos have won their last five away league matches, including two six-goal wins in succession.
Cristiano Ronaldo (pictured) has scored six of the 12 hat-tricks in La Liga this season. One of them was against Villarreal earlier in the season.
Ronaldo only needs three more goals to break the all-time Pichichi record of 38 goals in a single season.
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Rossi is Villarreal's answer to Cristiano Ronaldo. The Italian's prolific form in the second half of the season has been pivotal for the Yellow Submarine, scoring crucial goals when his team were struggling to help them secure a top-four finish.
All eyes are on the Portuguese ace, who is one more hat-trick away from surpassing La Liga's all-time Pichichi record of 38 goals in a single season. Another treble would also see him join Lionel Messi in breaking the 50 goal a season mark, as well as collect his second hat-trick of the campaign against Villarreal.
Real Madrid have nothing to play for after settling for second-place following Barcelona's La Liga triumph in midweek. Villarreal have safely booked their place in the Champions League play-offs, but they are stil mathematically in the running to snatch automatic qualification from Valencia. Only a win and a hope of a Los Che defeat will do, however. Jose Mourinho's men will be running low on motivation, but the Yellow Sub are not in the best of form to take advantage.