Both sides will hope to start with a bang...
Much against the odds and in spite of having a smaller squad than most other challengers, Sampdoria finished fourth in Serie A last season. That gave them the chance to play Champions League football but they were narrowly knocked out by Werder Bremen in the play-off round in midweek.
After losing 3-1 in Bremen in the first-leg last week Samp surged to a 2-0 lead early in the first-half and deep into injury time were 3-0 up, only for Bremen to score and take the tie to extra-time where Claudio Pizarro scored a stunner that knocked out the Genoese club.
Under new coach Domenico Di Carlo, who replaced Luigi Del Neri earlier this summer, the Blucerchiati will aim to repeat their heroics of last season but it wouldn't be easy for them. However, Samp went the entire league season unbeaten at the Marassi in 2009-10 and this will again be a key for them.
Ambitions Soaring High
Lazio supremo Claudio Lotito is not known for taking failures lightly and indeed after 2009-10's disastrous campaign in which the Aquile just about managed to stave off relegation to Serie B, finishing in mid-table, he has made it clear that this time such a failure wouldn't be tolerated.
Mark Bresciano, Gonzalo Barreto and Hernanes have been added to the squad, although Lazio have allowed Thomas Hitzlsperger to leave on a free transfer and Aleksandar Kolarov has been sold to Manchester City.
A top six finish is what Lazio should realistically attempt for, and with Edoardo Reja at the helm they can aspire to such lofty ambitions.
Sammarco, Tissone, Rossini and Koman are out. Cassano and Pazzini will again line up as the front-two.
Probable Lineup (4-4-2): Curci, Zauri, Gastaldello, Lucchini, Ziegler; Semioli, Palombo, Dessena, Mannini; Pazzini, Cassano
Bresciano is out and so are Firmani, Meghni and Garrido. Cribari is suspended.
Probable Lineup (3-4-2-1): Muslera, Biava, Dias, Radu; Lichsteiner, Ledesma, Matuzalem, Del Nero; Hernanes, Zarate; Floccari