Chelsea need to beat Tottenham as they face a battle to secure Champions League football for next season with five points between them and their rivals, who sit in fourth place ahead of Sunday's game.
However, Tottenham have history against them as they haven't won a league game at Stamford Bridge since 1990.
Both Chelsea and Tottenham consider each other their fiercest rivals and, with so much riding on this game, it will likely be a classic.
Thibaut Courtois is a doubt for Sunday's game with a hamstring injury, he is joined by Andreas Christensen who has muscular fatigue.
David Luiz is out for three more weeks, while Ross Barkley is training with the under-23s as he aims to return to first team action after a spate of injuries.
Tiemoue Bakayoko started the game against Leicester City and he has returned, but Ethan Ampadu is out for the season after fracturing his ankle in the UEFA Youth League victory over Real Madrid.
Danny Drinkwater is another doubt, having not appeared since he started against Manchester City, at the beginning of March.
Chelsea currently have no players suspended. Spain striker Alvaro Morata is, however, two yellow cards away from a two-match ban after accumulating eight bookings.
Chelsea potential starting line-up
Alvaro Morata got his first goal of 2018 against Leicester City, after a two-and-a-half month goal drought, but he is likely to start against Tottenham on Sunday.
Willian and Eden Hazard are undroppable, while Willy Caballero will start, if Courtois remains out injured.
Gary Cahill has lost his place in the starting line up to Antonio Rudiger, as Chelsea have established their 3-4-3 formation as their primary one again in recent weeks.
Conte will go for his full strength line up in what is one of his side's most important games of the season. If Courtois and Christensen are out, then Cahill and Caballero will likely step into their place.
Tottenham team news
Tottenham have a relatively clean bill of health, but they may be without their talismanic striker Harry Kane who suffered an ankle injury against Bournemouth.
Mauricio Pochettino has hinted that Kane is in with a chance of returning, but Son Heung-Min is more likely to continue to deputise in the England international's absence.
Toby Alderweireld could return after spending a number of weeks out with a hamstring injury, he returned to play for Belgium, but may remain on the bench due to a stalemate in talks over a new contract.
Harry Winks may also miss out through an ankle injury.
TV channel & kick-off time
The match takes place at 16:00 GMT on Sunday and it will be shown live in the UK on Sky Sports.
Best Opta match facts
Chelsea are unbeaten in their last 27 home league matches against Spurs (W18 D9) since losing 2-1 in February 1990.
Spurs’ 25 games at Stamford Bridge without winning in the Premier League is the most that one team has played on one ground without a single victory in the competition.
Tottenham have won more points in Premier League London derbies this season than any other side (13 – W4 D1 L2).
The Blues are looking to do their first league double over Tottenham since the 2005-06 season.
Chelsea are looking to secure back-to-back Premier League wins for the first time since December – they’re winless in their last four against fellow ‘big six’ sides (D2 L2), although all of those have been away from home.