Fernando Vazquez will take charge of the Galician outfit for the rest of the season after the Portuguese decided to leave his post following the 3-0 loss to Granada on Saturday
The Riazor club currently sit at the bottom of La Liga, six points from safety, and Fernando Vazquez will oversee their bid to stay in the top flight.
"Something has to change, and if that means me leaving, I will do what the club want," he told reporters after Saturday's 3-0 home loss to Granada.
"The situation is not easy, and I am worries about Depor."
Deportivo have lost their last four Liga mathces, and have won just once since the beginning of November.
Vazquez had previously taken their local rivals Ceta Vigo to the Uefa Cup.