Kagisho Dikgacoi will make an emotional return to Craven Cottage to witness his former club Fulham play their final Premier League game before being officially relegated to the Championship.
Palace head into this clash at the back of their sensational comeback that saw them draw 3-3 with Liverpool on Monday night; the result that blew Brendan Rodgers' chances of winning the Premier League title. However KG was poor on the night with a number of mistakes as Liverpool took a 3-0 lead, and after he was substituted the game turned around.
Dikgacoi began his European career as a 24-year-old with Fulham, but he was later loaned out to the Championship where he made a name for himself with the Eagles, and the South African midfielder will want to prove that they made a mistake in letting him go.
Steven Pienaar's Everton will look to consolidate their place in next season's Europa League with a point at Hull City on Saturday, after missing out on Uefa Champions League qualification.
The former Bafana Bafana skipper hasn't featured in recent games as manager Roberto Martinez believed that he's not yet fit to return to action, following his knee injury.
It remains to be seen if Schillo will form part of Everton's squad that will travel this weekend as he has fully recovered from the injury that kept him on the sidelines for a long period of time.
In League One division, Kgosi Ntlhe will be involved in a promotion play-off match when Peterborough United host Leyton Orient on Saturday afternoon.
Ntlhe and his Peterborough teammates finished sixth in the standings and they will begin their road to the Championship division with a tough game against Orient, who finished third at the end of the League One season.
South African midfielder Andile Jali could see himself competing in the Europa League next season should KV Oostende edge Darren Keet's KV Kortrijk on Monday night.
Oostende held Kortrijk to a 2-2 draw in the first leg of the final played on Friday, where Jali played the entire 90 minutes. And the former Orlando Pirates man will fight to help his team and maintain their impressive home record in the play-offs.
Unfortunately, former Bidvest Wits and SA U/23 goalkeeper, Keet, will not be part of the match as he's still nursing a shoulder injury, but he'll be behind his teammates on the night, knowing that he could be the one between the sticks in the Europa League next season.
Ayanda Patosi's KSC Lokeren will be away to Zulte-Waregem in the championship play-off match on Saturday. The South African attacker hasn't seen much game time recently, but he will be hoping to feature this weekend.
Anele Ngcongca will look to put in a solid performance when his side Racing Genk visit Anderlecht on Sunday evening.
The South Africa international has reportedly attracted interested from several clubs in Turkey including Olympiakos, and he will be aiming to impress those who are keeping an eye on him in Belgium.
May Mahlangu's IFK Goteborg will be at home against Oerebro in the Allsvenskan on Sunday, where the Bafana midfielder is expected to lift his teammates to a higher position on the log.
Goteborg lie sixth in the standings, six points behind log leaders Malmo FF, with 13 points from their first eight league games.
Mark Mayambela's Djurgaardens will be away to Falkensbergs FF on Monday night. Djurgaardens have not been bad at all this season as they are currently fifth in the standings with 13 points after eight games.