With the season moving into its final stretch, South Africa's contingent of European-based players will need to be on point this weekend in order to achieve their ambitions
The prospects of European football is high on the list of players like Steven Pienaar, while Crystal Palace's Kagisho Dikgacoi is aiming for promotion into the upper echelons of British football.
Former Bafana Bafana captain Steven Pienaar is still in the running for a spot in the Champions League next season as Everton host Stoke this weekend. The Toffees sit in sixth spot on the English Premier League log, merely two points behind Arsenal and six behind Tottenham Hotspur.
Kagisho Dikgacoi will continue to be a vital cog in Crystal Palace's midfield when they do battle against Birmingham City tonight, with the Eagles only three points away from a direct passage into the Premier League.
Dean Furman will play his second game in the colours of Doncaster Rovers tonight, while Kgosi Nthle will also be in action for Peterborough as his side continues to fight for promotion into League One.
In Belgium, Anele Ngongca's Genk will play Belgian PRO League leaders Anderlecht on Monday. Ngcongca's side is aiming for Europa League football next season. Daylon Claasen will also take to the pitch for Lierse while Darren Keet will hope to help Kortjik keep another clean sheet this weekend.
In Israel Dino Ndvlou and Dani Amos will both be in action with Ndlovu's Maccabi Haifa facing Maccabi Tel Aviv in a top of the table clash.
Siyanda Xulu's FC Rostov will seek breathing room in the fight for survival in Russia as they lock horns against Dinamo Moskva away from home on Saturday.
Meanwhile periodical benchwarmers Bongani Khumalo and Thulani Serero will most probably sit out when their side's PAOK and Ajax play this weekend.