Sangweni was the second defender to pull out of the squad following a recurrence of a knee injury, while Masilela may require surgery for his damaged knee cartiladge.
Mulomowandau Mathoho and Tebogo Langerman were selected as replacements for the injured duo and are just as effective according to Gordon Igesund.
"I think the squad has enough quality to provide cover for their absence. I think Siyanda Xulu adds value and Thabo Nthethe has proven how solid he is. I’ve got the necessary coverage in all areas," Igesund said at a news conference in Cape Town.
"Obviously it’s disappointing to lose players but there is no point moping about it. We’ve got to overcome these obstacles."
Igesud believes that Cape Town is an ideal venue for Bafana Bafana, "There are very few teams, at club and national team level, that ever come away from Cape Town with anything.
"This is a tough place to play. The players enjoyed it down here last time and the stadium is ideal, with a slick surface and a wide pitch that we hope will stretch our opponents."
Igesund has studied CAR closely before the tie and believes the side will prove to be a tough clash for Bafana.
"We are not going to under-estimate them.
"They have a tough physical team. It is a lot easier these days with modern technology to be able to study these teams.
"This is obviously a game we have to win because we are in a tricky situation in the group, but I’m confident in my players."