The Toffees have an excellent recent record against the big-spending Citizens, having won five of the last six meetings between the two clubs.
Pienaar showed glimpses of better form in midweek as Everton were held 1-1 at home by Arsenal, and will relish the opportunity to steal the limelight against City.
Bafana Bafana midfielder Dean Furman can create a fairytale scenario with League One Oldham Athletic as they play in the second round of the FA Cup against Doncaster Rovers.
If The Latics can get through this tie, they could set up a plumb tie against a Premiership side in the third round in early January.
These two met on Tuesday in the League, with Doncaster winning 1-0 at home.
Kagisho Dikgacoi’s Crystal Palace will look to return to the summit of the English Championship when they host Brighton & Hove Albion on Saturday.
A defeat at Leeds United and a draw with Hull City has broken the momentum of The Eagles, but they will welcome back leading scorer Glenn Murray from suspension.
Bongani Khumalo will hope to win his place back in the PAOK side as they travel to struggling Veria on Saturday, the side that Calvin Kadi helped win promotion last season. Khumalo was on the bench for the 1-1 draw with league leaders Olympiakos last weekend.
Likewise Siyanda Xulu, who found himself back on the bench for Russian Premier League side FC Rostov last time out. They are away at Krylya Sovetov on Sunday.
In Belgium, Anele Ngcongca’s Genk take on Ayanda Patosi’s Lokeren in a top-of-the-table clash on Sunday.
The pair have developed a keen friendship in their time in Belgium, and could well be thrust together. Ngcongca takes up a right-back position and Patosi finds himself on the left-wing.
No team in the Belgian top-flight has conceded fewer goals than Kortrijk’s 15 this season and goalkeeper Darren Keet takes that proud record to Charleroi on Saturday.Lance Davids will hope to win favour with new coach Hany Ramzy as Lierse entertain Mons. Davids has yet to feature this season having been frozen out by former coach Chris Janssens.