The San Paolo showdown had been set to go ahead on the first Saturday after the international break but it has been moved because of a clash with a planned protest in the City
The game at the San Paolo had been scheduled to go ahead on the first Saturday after the current international break but that would have seen the top-of-the-table encounter clash with a planned protest in Naples.
Given the strain that would have placed upon the city's police force, Lega Calcio has now decided to move the match to the Friday night.
"Roma-Napoli is clearly a game that must be played and it makes no sense that we pit ourselves against one another, but this solution causes more [logistical] problems for us than the Giallorossi," the Napoli supremo told reporters on Monday.
"The most important thing, however, is that a solution has been found that gives due prominence to the game.
"Right now we are talking about a match that can be considered as the game of games."
Roma have won all seven of their Serie A fixtures so far this season, while second-placed Napoli have dropped just two points.