It had been claimed that die Schwarzgelben were interested in the Belgian but even the player's agent insists there is no chance of him leaving Stamford Bridge
Despite featuring in the Blues' opening two games of the new Premier League season, the Belgium international has reportedly fallen out of favour with coach Jose Mourinho.
However, Klopp insists there is no truth in the rumour that Dortmund are considering signing De Bruyne on loan.
"We have signed great players over the summer," Klopp told Deutsche Presseagentur. "We have a squad we are very happy with.
"He [De Bruyne] is actually not one we are after. He is at Chelsea, and given the size and quality of the Chelsea first-team squad, it's quite usual he may sometimes miss out on one or two matches."
Furthermore, while De Bruyne spent last season on loan with another Bundesliga outfit, Werder Bremen, the 22-year-old's agent, Patrick De Koster, is adamant that there is no chance of his client leaving Stamford Bridge before the end of the season.
"This summer we decided to stay with Chelsea, and we knew the competition would be hard and that Kevin had to fight," he told Bild.
"He will continue fighting. I have no contact to other clubs. Even if we were in the transfer period, I would not have any contact."
De Bruyne joined Chelsea from Racing Genk last summer before immediately being sent to the Weserstadion.