David Moyes' first league match in charge of the champions will be against the Capital One Cup holders while Jose Mourinho begins his second spell at Chelsea against promoted Hull
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Jose Mourinho, meanwhile, will begin the start of his second spell in charge of Chelsea against newly promoted Hull City and last season's runners-up Manchester City host Newcastle in what will be Manuel Pellegrini's first league game in charge.
Elsewhere, Championship play-off winners Crystal Palace will host Tottenham in a London derby, while Arsenal host Aston Villa and Stoke visit Liverpool.
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The first meeting of the Manchester powerhouses is due to take place on September 21 at the Etihad Stadium, while the return fixture is scheduled for March 1.
United will complete their league fixtures against Southampton at St Mary’s, while rivals Manchester City are scheduled to entertain West Ham on the final day. Chelsea will finish against last season’s Championship winners Cardiff, while Arsenal are due to travel to Norwich and Tottenham will host Aston Villa.
The fixture list - which can be seen in full with our club-by-club guide - has served up a host of box office clashes, including Mourinho's first reunion with former protege Andre Villas-Boas - one of Goal's 10 games to look out for next season.
The Football League fixtures were also released today, which can be seen here, with relegated Premier League outfits QPR and Reading handed home ties, while FA Cup holders Wigan take on Barnsley.