The 32-year-old centre-back feels that, with the emergence of Roberto Mancini's side in recent seasons, the fixture against United now represents the largest in the top flight
With Roberto Mancini's side sure to relinquish their league crown over the coming weeks after falling 15 points behind United in the title race this season, the fixture won't retain the same significance as previous clashes between the two.
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"Back when I was playing in north London derbies, it was only Arsenal and Manchester United fighting for the title and that was the biggest competition but today it's more like City and United," Toure told the champions' official website.
"We need to try and win this game - we don’t want other teams to catch us because we want to make sure we get second but at the same time we want to close the gap at the top.
"It will be a tough game, we know the title is difficult and that they are in front of us.
"It’s going to be really important mentally for us – we lost the game at home and it’s important for us to try and win it back.
"We played a great game against Newcastle but now we need to be focused, prepared and to give 100 per cent on Monday."