The Italy striker will be absent through injury as coach Clarence Seedorf looks to extend a run of just one defeat from his first five games in charge
AC Milan will be without Mario Balotelli when they travel to Sampdoria in Serie A on Sunday.
The Italy striker has scored four of the Rossoneri's seven goals since the arrival of Clarence Seedorf as coach in January, but a shoulder injury will force him to miss the trip to the Luigi Ferraris.
Balotelli picked up the problem in Wednesday's 1-0 defeat to Atletico Madrid in the first-leg of their Champions League last-16 tie.
Seedorf's appointment has improved the domestic form of Milan, who have lost just one of five Serie A games since the Dutchman replaced Massimiliano Allegri.
However, their faint hopes of securing European football with a top-five finish could well suffer a blow at a stadium where the 18-time champions have struggled to earn positive results.
Indeed, Milan have not won a league game at Sampdoria since October 2007, when Seedorf scored the final goal in an emphatic 5-0 win.
Injuries at both ends of the pitch may hamper the Rossoneri's chances of ending that run, with Mattia De Sciglio (ankle) also having picked up an injury in midweek.
The absence of the right-back and Balotelli will come as a blow to a side already missing several first-team players, including strikers Robinho (thigh) and Stephan El Shaarawy (foot).
Valter Birsa (hamstring), Bryan Cristante (leg) and Matias Silvestre (calf) are also unavailable, while the suspended pair of defender Daniele Gastaldello and midfielder Lorenzo Di Silvestri miss out for Samp.
Striker Maxi Lopez, scorer of the winning goal in the derby against fierce rivals Genoa earlier this month, is nearing a return from a foot injury, but Gianluca Sansone is a doubt through illness.
Samp were hammered 3-0 by Roma last weekend but are nine points clear of the drop zone despite an inconsistent campaign.