Costel Pantilimon could start for the visitors against a Magpies side hoping to bounce back from a crushing derby defeat at the hands of struggling rivals Sunderland
Alan Pardew's side slumped to a 2-1 defeat in the Tyne-Wear derby against Sunderland at the Stadium of Light on Sunday, a result which gave their fierce rivals their first league win of the season.
Mathieu Debuchy thought he had rescued a point for the Magpies when he cancelled out Steven Fletcher's early opener, but a superb late strike from Fabio Borini handed Sunderland all three points in Gus Poyet's first home game in charge.
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One of those reverses came at City on the opening weekend of the Premier League season, when Manuel Pellegrini's men ran riot in a 4-0 victory.
Pardew has no fresh injury worries ahead of Wednesday's clash at St James' Park. Ryan Taylor [knee] remains a long term absentee, while Fabricio Coloccini is unlikely to be risked as he continues his recovery from a groin injury.
Pellegrini, meanwhile, will also look to get his charges back on track after they fell to their third Premier League defeat of the season in a 2-1 defeat to fellow title hopefuls Chelsea on Sunday.
Sergio Aguero looked to have earned City a draw when he equalised Andre Schurrle's first half opener, but a mix-up between Joe Hart and Matija Nastasic allowed Fernando Torres to tap home a late winner.
Hart is likely to be rested in the cup clash at St James' Park, with Costel Pantilimon expected to step in for the visitors.
Captain Vincent Kompany will be unavailable for the fixture, meanwhile, as he continues his comeback from a thigh injury.
City hammered Wigan Athletic 5-0 in the round three of the Capital One Cup, while Newcastle have defeated Morecambe and Leeds United to make it to this stage.