England will step up their World Cup preparations with a trip to Amsterdam to face a Netherlands side working under Ronald Koeman for the first time.
The Three Lions breezed through another qualification campaign, but there are still plenty of questions to be answered before they head to Russia.
The Dutch, meanwhile, find themselves in a period of transition after failing to reach a major tournament for the first time since 2002.
Koeman has been charged with the task of turning their fortunes around, with a man who earned 78 caps in his playing days back in the international fold following a previous stint as assistant to Guus Hiddink.
|Game||Netherlands vs England|
|Date||Friday March 23|
TV Channel & Live Stream
In the United Kingdom (UK), the game can be watched live on TV on ITV and streamed via ITV Hub.
|UK TV channel||Online stream|
Squads & Team News
|Goalkeepers||Bizot, Cillessen, Zoet|
|Defenders||Van Aanholt, Ake, Van Dijk, Fosu-Mensah, Hateboer, De Ligt, Tete, De Vrij|
|Midfielders||Van de Beek, Proepper, De Roon, Strootman, Til, Vilhena, Wijnaldum|
|Forwards||Babel, Berghuis, Depay, Dost, Kluivert, Promes, Weghorst|
Koeman has included five uncapped players in his first squad, including exciting 18-year-old Ajax winger Justin Kluivert - the son of former Netherlands striker Patrick.
AZ Alkmaar trio Marco Bizot, Guus Til and Wout Weghorst are also new to the fold, along with Atalanata defender Hans Hateboer.
There is plenty of experience to counter the fresh faces, although all-time leading appearance maker Wesley Sneijder has announced his international retirement and Robin van Persie is still waiting on a recall.
Potential Netherlands XI: Cillessen; Fosu-Mensah, De Vrij, Van Dijk, Ake, Van Aanholt; Wijnaldum, Propper, Strootman; Memphis, Dost
|Goalkeepers||Hart, Pickford, Butland, Pope|
|Defenders||Walker, Tripper, Rose, Stones, Tarkowski, Mawson, Gomez, Maguire|
|Midfielders||Dier, Henderson, Livermore, Lallana, Oxlade-Chamberlain, Alli, Sterling, Young, Lingard, Cook|
|Forwards||Welbeck, Vardy, Rashford|
Nick Pope, James Tarkowski and Alfie Mawson have been handed maiden call-ups to the Three Lions fold, while Lewis Cook is looking for his first cap.
Arsenal midfielder Jack Wilshere had been recalled after two years in the international wilderness but has now been ruled out of the fixture due to a knee injury.
Joe Hart retains his place in the squad despite a difficult loan spell at West Ham but Southgate has confirmed it is Jordan Pickford who will start in Amsterdam.
Tottenham striker Harry Kane is missing through injury, while Southampton full-back Ryan Bertrand has returned to his club as a precautionary measure after picking up a back complaint.
Potential England XI: Pickford; Walker, Dier, Stones, Maguire, Young; Henderson, Oxlade-Chamberlain; Alli, Vardy, Sterling
Betting & Match Odds
Netherlands start as slight favourites to win the game with dabblebet, who price them at 6/4.
England are 9/5 to claim victory and a draw is available at 21/10.
England may be using a meeting with the Netherlands, and a clash with Italy at Wembley next week, to experiment a little, but they need to start settling on a preferred XI.
Southgate's biggest selection headache comes between the sticks, with there no obvious choice to fill goalkeeping duties heading into the World Cup.
With four options available in the latest Three Lions squad, all of those in the running for a starting berth should expect to see some game time.
England may also take the opportunity to explore their options in a three-man defensive unit - a favoured approach of Southgate - with Tottenham's Eric Dier able to slip back from midfield into a centre-half berth.
Victory may not be the priority at this stage, with friendlies offering an opportunity to tinker, but momentum and confidence needs to start being built with competitive football now a matter of months away.
For the Dutch, Koeman will be looking to rebuild on the back of a disappointing qualification campaign.
He has plenty of potential at his disposal, but unlocking that may be easier said than done.
A meeting with England may be just what they need to rediscover their spark, with the Oranje unbeaten in their last seven meetings with the Three Lions stretching back to a 4-1 defeat at Euro 96.