The Atletico Madrid boss paid tribute to the former coach after his side claimed the Liga title with a 1-1 draw at Barcelona.
Needing just a point at Camp Nou on the final day of the season to claim their 18th La Liga title, Atletico found itself behind at the break thanks to Alexis Sanchez's brilliant strike.
But Diego Godin's second-half header ensured the visitors claimed the draw it needed in a dramatic second half that also saw Lionel Messi have a goal ruled out for offside.
Former Atleti and Spain coach Aragones died in February, and Simeone said he felt as though the ex-Rojiblancos striker were defending along with the team at Camp Nou.
"It's amazing," Simeone said. "You can't explain it. I have to thank the players, the people who trusted us. We've never stopped working and that's why we're here. Today is one of the best days in the history of Atleti. To be champions in Barcelona against a team like this, the champions of all in recent years.
"I'm sure Luis Aragones was defending for us in the second half."
Alexis' goal gave Barca a halftime lead which would have been enough to see it defend the title, but Simeone says he was quick to keep his players calm at the break.
"At halftime I told them to be relaxed," he said. "In the first half we did well. I knew if we scored, it would cost them. That's what happened. There was an amazing collective effort from everyone."
Simeone now turns his attention to next weekend's Champions League final against city rivals Real Madrid, which claimed the Copa del Rey earlier this season.
"I tell the fans we look forward to seeing them all, to see Madrid in red and white," he added. "Today we are making history, but we have to prepare for the final on Saturday."